√   Chem. Eur. J. 2021, 27, 11291-11297

Iminosugar C-glycosides work as pharmacological chaperones of NAGLU, a glycosidase involved in MPS IIIB rare disease

S. Zhu, Y. Jagadeesh, A.T. Tran, A. Yamamoto, D. Alonzi, A. Poveda, Y. Zhang, A. Kato, A. Boraston, T. Butters, J. Désiré, J. Charollais-Thoenig, S. Demotz, J. Jiménez-Barbero, M. Sollogoub, Y. Blériot



√   Acc. Chem. Res. 2021, 54(11), 2552-2564

Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity and Interactions

A. Franconetti, A. Arda, J. L. Asensio, Y. Blériot, S. Thibaudeau, J. Jiménez-Barbero


Front Cover of Acc. Chem. Res. 2021


√   Carbohydr. Res. 2021, 501, 108258

Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an Aza Crown IminoSugar structure

A. Bordes, A. Poveda, N. Fontelle, A. Arda,  J. Guillard, Y. Bin Ruan, J. Marrot, S. Imaeda, A. Kato, J. Désiré, J. Xie, J. Jiménez-Barbero,  Y. Blériot



√   Angew. Chem. Int. Ed. 2021, 60(4), 2036-2041

Insight in the Ferrier rearrangement by combining flash chemistry and Superacids

N. Bhuma, L. Lebedel, H. Yamashita, Y. Shimizu, Z. Abada, A. Ardá, J. Désiré, B. Michelet, A. Martin-Mingot, A. Abou-Hassan, M. Takumi, J. Marrot, J. Jiménez-Barbero, A. Nagaki, Y. Blériot, S. Thibaudeau



√   Synthesis 2021, 53 (5), 904-924

Contributing to the Study of Enzymatic and Chemical Glycosyl Transfer Through the Observation and Mimicry of Glycosyl Cations

Y. Blériot




√   Org. Lett. 2020, 22(6), 2344-2349

Synthesis, conformational analysis and complexation study of an iminosugar-aza-crown, a sweet chiral cyclam analog

A. Bordes,  A. Poveda, T. Troadec, A. Franconetti, A. Ardá, F. Perrin, M. Ménand, M. Sollogoub, J. Guillard, J. Désiré, R. Tripier, J. Jiménez-Barbero, Y. Blériot



√   Angew. Chem. Int. Ed. 2019, 58(39), 13758-13762

Structural and Computational Analysis of 2-Halogeno-Glycosyl Cations in Superacid: An Expansive Platform

L. Lebedel, A. Ardá, A. Martin, J. Désiré, A. Mingot, M. Aufiero, N. Aiguabella Font, R. Gilmour, J. Jiménez-Barbero, Y. Blériot, S. Thibaudeau


√   Org. Biomol. Chem. 2019, 17, 7204-7214

Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C-allyl iminosugar

Q. Foucart, Y. Shimadate, J. Marrot, A. Kato, J. Désiré, Y. Blériot




√   Org. Lett. 2019, 21(12), 4821-4825

Site-selective debenzylation of C-allyl iminosugars enables their stereocontrolled structure diversification at the C-2 position

Q. Foucart, J. Marrot,  J. Désiré, Y. Blériot





√   ACS Central Science  2019, 5(5), 781-788

Defining the SN1 side of glycosylation reactions: stereoselectivity of glycopyranosyl cations

, , , , , , , , , , , ,


Front Cover of ACS Cent. Sci.



√   J. Carb. Chem. 2019, 38:2, 139-149

Bi(OTf)3-mediated intramolecular epoxide opening for bicyclic azepane synthesis

S. Zhu, A. T. Tran, Y. Hirokami, G. Gontard, O. Khaled, Y. Zhang, A. Kato, Y. Blériot, M. Sollogoub




√   Carbohydr. Res. 2019, 472, 65-71

Lewis acid-catalysed nucleophilic opening of a bicyclic hemiaminal followed by ring contraction: access to functionalized L-idonojirimycin derivatives

N. Auberger, B. Onfroy, N. Fontelle, Q. Foucart, Y. Blériot




√   Eur. J. Org. Chem. 2018, 40, 5477-5488

2-Acetamido-2-deoxy-L-iminosugar C-alkyl and C-aryl glycosides: synthesis and glycosidase inhibition

N. Fontelle, A. Yamamoto, A. Arda, J. Jiménez-Barbero, A. Kato, J. Désiré, Y. Blériot



Feature Cover of Eur. J. Org. Chem.



√   Org. Biomol. Chem. 2017, 15, 9297-9304

2017 Hot Articles and Cover Page in Organic and Biomolecular Chemistry

In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease

A. Kato, I. Nakagome, S. Nakagawa, K. Kinami, I. Adachi, S. F. Jenkinson, J. Désiré, Y. Blériot, R. J. Nash, G. W. J. Fleet, S. Hirono




Front Cover of Org. Biomol. Chem.



√   Nat. Commun.  2017, 8:115

Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia
mallei lipopolysaccharide O-antigens

M. Tamigney Kenfack, M.Mazur, T. Nualnoi, T. L. Shaffer, A. Ngassimou, Y.Blériot, J. Marrot, R. Marchetti, K. Sintiprungrat, N. Chantratita, A. Silipo, A. Molinaro, D. P. AuCoin, M. N. Burtnick, P. J. Brett & Ch. Gauthier






√  Carbohydrate Chem. Prov. Synth. Meth. 2017, Part I: Synthetic Methods, Chapter 6

One Step Preparation of Protected Ntert-Butanesulfinyl d-ribo and d-xylo furanosylamines from Related Sugar Hemiacetals

Cocaud, C., Nicolas, C., Désiré, J., Martin. O. R.



√   Chem. Eur. J.  2017, 23 (38), 9022-9025

Multivalency to inhibit and discriminate hexosaminidases

D. Alvarez-Dorta, D. T. King, T. Legigan, D. Ide, I. Adachi, D. Deniaud, J. Désiré, A. Kato, D. J. Vocadlo, S. Gouin, Y. Blériot




√   Org. Biomol. Chem. 2017, 15, 4609-4619

Selective trihydroxylated azepane inhibitor of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics

J. Bouquet, D. T. King, G. Vadlamani, G. Benzie, B. I. Iorga, D. Ide, I. Adachi, A. Kato, D. J. Vocadlo, B. L. Mark, Y. Blériot, J. Désiré




√   Protein Science 2017, 26 (6), 1161-1170

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

G. Vadlamani, K. A. Stubbs, J. Désiré, Y. Blériot, D. J. Vocadlo, B. L. Mark




√   Org. Lett. 2017, 19, 1040-1043

HF-induced intramolecular C-arylation and C-alkylation/fluorination of 2-aminoglycopyranoses

N. Probst, A. Martin, J. Désiré, A. Mingot, J. Marrot, Y. Blériot, S. Thibaudeau



√   Nat. Chem. 2016, 8, 186-191

Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid

A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinaÿ, J. Jiménez-Barbero, S. Thibaudeau, Y. Blériot




√  J. Med. Chem. 2016, 59, 9350-9369

New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues

L. Zimmermann, I. Das, J. Désiré, G. Sautrey, V. Barros, M. El Khoury, M.-P. Mingeot-Leclercq, J.-L. Décout


√  J. Org. Chem. 2016, 81, 10585-10599

4′-Methoxyphenacyl-Assisted Synthesis of β-Kdo Glycosides

M. Mazur, B. Barycza, M. Tamigney Kenfack, Y. Blériot, C. Gauthier


√  Org. Biomol. Chem. 2015, 13, 10734-10744

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors

V. Cendret, T. Legigan, A. Mingot, S. Thibaudeau, I. Adachi., M. Forcella, P. Parenti, J. Bertrand, F. Becq, C. Norez, J. Désiré, A. Kato, Y. Blériot



√  Chem. Eur. J. 2015, 21, 10513-10521

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings

L. Unione, B. Xu, D. Díaz, S. Martín-Santamaría, A. Poveda, J. Sardinha, A. Pilar Rauter, Y. Blériot, Y. Zhang, F. Javier Cañada, M. Sollogoub, J. Jiménez-Barbero




√  Carbohydr. Res. 2015, 409, 56-62

Synthesis of pyrrolidines-based analogues of aminosugars as N-acetyl glucosaminidase inhibitors

A. T. Tuan, Y. Jagadeesh, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot



 √  Org. Biomol. Chem. 2015, 13, 3446-3456

γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

Y. Jagadeesh, A. T. Tuan, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot




√  Nature Communications 2014, 5, 5354

Site-selective hexa-hetero-functionalization of a-cyclodextrin an archetypical C6-symmetric concave cycle

B. Wang, E. Zaborova, S. Guieu, M. Petrillo, M. Guitet, Y. Blériot, M. Ménand, Y. Zhang & M. Sollogoub


√  Angew. Chem. Int. Ed. 2014, 53(36), 9597-9602

gem-Difluorocarbadisaccharides: Restoring the exo-Anomeric Effect

B. Xu, L. Unione, J. Sardinha, S. Wu, M. Ethève-Quelquejeu,  A. Pilar Rauter, Y. Blériot, Y. Zhang, S. Martín-Santamaría, D. Díaz,  J. Jiménez-Barbero, M. Sollogoub



√ Org. Lett. 2014, 16(21), 5512-5515

Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement

Y. Blériot, N. Auberger, Y. Jagadeesh, C. Gauthier, G. Prencipe, A. Tuan Tran, J. Marrot, J. Désiré, A. Yamamoto, A. Kato, M. Sollogoub



√   Org. Lett. 2014, 16(21), 5516-5519

Synthesis of 1,2-trans-2-acetamido-2-deoxyhomoiminosugars

Y. Blériot, A. Tuan Tran, G. Prencipe, Y. Jagadeesh, N. Auberger, S. Zhu, C. Gauthier, Y. Zhang, J. Désiré, I. Adachi, A. Kato, M. Sollogoub



√  Org. Biomol. Chem. 2014, 12(44), 8977-8996

N- and C-Alkylation of seven-membered iminosugars generate potent glucocerebrosidase inhibitors and F508del-CFTR correctors

J. Désiré, M. Mondon, N. Fontelle, S. Nakagawa, Y. Hirokami, I. Adachi, R. Iwaki, G. W. J. Fleet, D. S. Alonzi, G. Twigg, T. D. Butters, J. Bertrand, V. Cendret, F. Becq, C. Norez, J. Marrot, A. Kato, Y. Blériot



√  Carbohydrate Chemistry 2014, 40, 418-444

Conformationally restricted glycoside derivatives as mechanistic probes and/or inhibitors of sugar processing enzymes and receptors

C. Maaliki, C. Gauthier, O. Massinon, R. Sagar, S. P. Vincent, Y. Blériot



√  Carbohydrate Chem. Prov. Synth. Meth. 2014, 2, 85-96

Synthesis of fluorinated exo-glycals mediated by Selectfluor

G. Eppe, A. Caravano, J. Désiré, S. P. Vincent


  Chem. Commun. 2013, 49(93), 10983-10985

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

M. Mondon, S. Hur, G. Vadlamani, P. Rodrigues, P. Tsybina, A. Oliver, B. L. Mark, D. J. Vocadlo, Y. Blériot



√  Bioorg. Med. Chem. 2013, 21, 4831-4838

Novel imino sugar α-glucosidase inhibitors as antiviral compounds

J. D. Howe, N. Smith, M. J-R. Lee, N. Ardes-Guisot, B. Vauzeilles, J. Désiré, A. Baron, Y. Blériot, M. Sollogoub, D. S. Alonzi, T. D. Butters




√  Bioorg. Med. Chem. 2013, 21, 4803-4812

Skeletal rearrangement of seven-membered iminosugars: Synthesis of (−)-adenophorine, (−)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors

M. Mondon, F. Lecornué, J. Guillard, S. Nakagawa, A. Kato, Y. Blériot



√  Eur. J. Org. Chem. 2013, 13, 2583-2590

β-Cyclodextrin-glycerol dimers: synthesis and NMR conformational analysis

V. Legros, C. Vanhaverbeke, F. Souard, C. Len, J. Désiré



√   Org. Lett. 2012, 14(3), 870-873

Access to D- and L-Imino-Sugar C-Glycosides from a D-Gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

M. Mondon, N. Fontelle, J. Désiré, F. Lecornué, J. Guillard, J. Marrot, Y. Blériot



√  Carbohydr. Res. 2012, 361, 219-224

Synthesis and conformational analysis of bicyclic mimics of α- and β-D-glucopyranosides adopting the biologically relevant 2,5B conformation

L. Amorim, F. Marcelo, J. Désiré, M. Sollogoub, J. Jiménez-Barbero, Y. Blériot



Carbohydr. Res. 2012, 356, 278-281

Cyclodextrins selectively modified on both rims using an O-3-debenzylative post-functionalisation, a consequence of the Sorrento meeting

M. Guitet, S. Adam de Beaumais, Y. Blériot, B. Vauzeilles, Y. Zhang, M. Menand, M. Sollogoub

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√  J. Med. Chem. 2012, 55(13), 6021-6032

A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits HIV-1 Replication

I. Das, J. Désiré, D. Manvar, I. Baussanne, V. N. Pandey, J.-L. Décout


√  New J. Chem. 2012, 36, 1008-1013

Conformational analysis of seven-membered 1-N-iminosugars by NMR and molecular modelling

J. Pérez-Castells, M. Fontanella, A. Ardá, F. Javier Canãda, M. Sollogoub, Y. Blériot, J. Jiménez-Barbero


√  J. Carb. Chem. 2011, 30(7-9), 641-654

Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether-Bridged Iminosugars

B. Luo, F. Marcello, J. Désiré, Y. Zhang, M. Sollogoub, A. Kato, I. Adachi, F. J. Canada, J. Jimenez-Barbero, Y. Blériot





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