Publications

√   Chem. Eur. J.  2017, 23 (38), 9022-9025

Multivalency to inhibit and discriminate hexosaminidases

D. Alvarez-Dorta, D. T. King, T. Legigan, D. Ide, I. Adachi, D. Deniaud, J. Désiré, A. Kato, D. J. Vocadlo, S. Gouin, Y. Blériot

ChemEurJ-Multivalency-2017

 


 

√   Org. Biomol. Chem. 2017, 15, 4609-4619

Selective trihydroxylated azepane inhibitor of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics

J. Bouquet, D. T. King, G. Vadlamani, G. Benzie, B. I. Iorga, D. Ide, I. Adachi, A. Kato, D. J. Vocadlo, B. L. Mark, Y. Blériot, J. Désiré

OBC-NagZ-2017

 


 

√   Protein Science 2017, 26 (6), 1161-1170

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

G. Vadlamani, K. A. Stubbs, J. Désiré, Y. Blériot, D. J. Vocadlo, B. L. Mark

ProteinScience-NagZ-2017

 


 

√   Org. Lett. 2017, 19, 1040-1043

HF-induced intramolecular C-arylation and C-alkylation/fluorination of 2-aminoglycopyranoses

N. Probst, A. Martin, J. Désiré, A. Mingot, J. Marrot, Y. Blériot, S. Thibaudeau

OrgLett-HF-2017

 


√   Nat. Chem. 2016, 8, 186-191

Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid

A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinaÿ, J. Jiménez-Barbero, S. Thibaudeau, Y. Blériot

NatChem2016

NatChem-GlycosylCation-2016

NatChem-GlycosylCation-News&Views-2016


√  J. Med. Chem. 2016, 59, 9350-9369

New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues

L. Zimmermann, I. Das, J. Désiré, G. Sautrey, V. Barros, M. El Khoury, M.-P. Mingeot-Leclercq, J.-L. Décout

JMedChem-Aminosides-2016


√  J. Org. Chem. 2016, 81, 10585-10599

4′-Methoxyphenacyl-Assisted Synthesis of β-Kdo Glycosides

M. Mazur, B. Barycza, M. Tamigney Kenfack, Y. Blériot, C. Gauthier

JOrgChem-Kdo-2016


√  Org. Biomol. Chem. 2015, 13, 10734-10744

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors

V. Cendret, T. Legigan, A. Mingot, S. Thibaudeau, I. Adachi., M. Forcella, P. Parenti, J. Bertrand, F. Becq, C. Norez, J. Désiré, A. Kato, Y. Blériot

OBC2015-CVY

OBC-DNJ-2015


√  Chem. Eur. J. 2015, 21, 10513-10521

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings

L. Unione, B. Xu, D. Díaz, S. Martín-Santamaría, A. Poveda, J. Sardinha, A. Pilar Rauter, Y. Blériot, Y. Zhang, F. Javier Cañada, M. Sollogoub, J. Jiménez-Barbero

ChemEurJ2015-YB

ChemEurJ-Idopyranosides-2015


 

√  Carbohydr. Res. 2015, 409, 56-62

Synthesis of pyrrolidines-based analogues of aminosugars as N-acetyl glucosaminidase inhibitors

A. T. Tuan, Y. Jagadeesh, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot

car_6954_TOC.cdxml

CarbohydrRes-pyrrolidines-2015


 √  Org. Biomol. Chem. 2015, 13, 3446-3456

γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

Y. Jagadeesh, A. T. Tuan, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot

OBC2015-Jag

OBC-Pyrrolidines-2015


√  Angew. Chem. Int. Ed. 2014, 53(36), 9597-9602

gem-Difluorocarbadisaccharides: Restoring the exo-Anomeric Effect

B. Xu, L. Unione, J. Sardinha, S. Wu, M. Ethève-Quelquejeu,  A. Pilar Rauter, Y. Blériot, Y. Zhang, S. Martín-Santamaría, D. Díaz,  J. Jiménez-Barbero, M. Sollogoub

Angew2014-YB

Angew-ExoAnomeric-2014


√ Org. Lett. 2014, 16(21), 5512-5515

Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement

Y. Blériot, N. Auberger, Y. Jagadeesh, C. Gauthier, G. Prencipe, A. Tuan Tran, J. Marrot, J. Désiré, A. Yamamoto, A. Kato, M. Sollogoub

OL2014-2

OrgLett1-Homoiminosugars-2014


√   Org. Lett. 2014, 16(21), 5516-5519

Synthesis of 1,2-trans-2-acetamido-2-deoxyhomoiminosugars

Y. Blériot, A. Tuan Tran, G. Prencipe, Y. Jagadeesh, N. Auberger, S. Zhu, C. Gauthier, Y. Zhang, J. Désiré, I. Adachi, A. Kato, M. Sollogoub

OL2014

OrgLett2-Homoiminosugars-2014


√  Org. Biomol. Chem. 2014, 12(44), 8977-8996

N- and C-Alkylation of seven-membered iminosugars generate potent glucocerebrosidase inhibitors and F508del-CFTR correctors

J. Désiré, M. Mondon, N. Fontelle, S. Nakagawa, Y. Hirokami, I. Adachi, R. Iwaki, G. W. J. Fleet, D. S. Alonzi, G. Twigg, T. D. Butters, J. Bertrand, V. Cendret, F. Becq, C. Norez, J. Marrot, A. Kato, Y. Blériot

OBC2014-NF-CVY

OBC-alkylazepanes-2014


√  Carbohydrate Chemistry 2014, 40, 418-444

Conformationally restricted glycoside derivatives as mechanistic probes and/or inhibitors of sugar processing enzymes and receptors

C. Maaliki, C. Gauthier, O. Massinon, R. Sagar, S. P. Vincent, Y. Blériot

CarbChem2014-YB


 

√  Carbohydrate Chem. Prov. Synth. Meth. 2014, 2, 85-96

Synthesis of fluorinated exo-glycals mediated by Selectfluor

G. Eppe, A. Caravano, J. Désiré, S. P. Vincent

ProvenMethods


  Chem. Commun. 2013, 49(93), 10983-10985

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

M. Mondon, S. Hur, G. Vadlamani, P. Rodrigues, P. Tsybina, A. Oliver, B. L. Mark, D. J. Vocadlo, Y. Blériot

ChemComm2013-MM

ChemComm-NagZ-2013


√  Bioorg. Med. Chem. 2013, 21, 4831-4838

Novel imino sugar α-glucosidase inhibitors as antiviral compounds

J. D. Howe, N. Smith, M. J-R. Lee, N. Ardes-Guisot, B. Vauzeilles, J. Désiré, A. Baron, Y. Blériot, M. Sollogoub, D. S. Alonzi, T. D. Butters

BMC2013-Boris

BMC-Antivirals-2013



 

√  Bioorg. Med. Chem. 2013, 21, 4803-4812

Skeletal rearrangement of seven-membered iminosugars: Synthesis of (−)-adenophorine, (−)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors

M. Mondon, F. Lecornué, J. Guillard, S. Nakagawa, A. Kato, Y. Blériot

BMC2013-MM

BMC-Adenophorine-2013


√  Eur. J. Org. Chem. 2013, 13, 2583-2590

β-Cyclodextrin-glycerol dimers: synthesis and NMR conformational analysis

V. Legros, C. Vanhaverbeke, F. Souard, C. Len, J. Désiré

 EurJOC2013-Vanessa

EurJOC-DimerCD-2013


√   Org. Lett. 2012, 14(3), 870-873

Access to D- and L-Imino-Sugar C-Glycosides from a D-Gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

M. Mondon, N. Fontelle, J. Désiré, F. Lecornué, J. Guillard, J. Marrot, Y. Blériot

OL2012

OrgLett-Iminosugar-C-glycosides-2012


√  Carbohydr. Res. 2012, 361, 219-224

Synthesis and conformational analysis of bicyclic mimics of α- and β-D-glucopyranosides adopting the biologically relevant 2,5B conformation

L. Amorim, F. Marcelo, J. Désiré, M. Sollogoub, J. Jiménez-Barbero, Y. Blériot

CarbRes2012

CarbohydrRes-Conformations-2012


Carbohydr. Res. 2012, 356, 278-281

Cyclodextrins selectively modified on both rims using an O-3-debenzylative post-functionalisation, a consequence of the Sorrento meeting

M. Guitet, S. Adam de Beaumais, Y. Blériot, B. Vauzeilles, Y. Zhang, M. Menand, M. Sollogoub

Microsoft Word - Graphical-revision.doc

CarbohydrRes-CD-2012


√  J. Med. Chem. 2012, 55(13), 6021-6032

A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits HIV-1 Replication

I. Das, J. Désiré, D. Manvar, I. Baussanne, V. N. Pandey, J.-L. Décout

JMedChem2012JMedChem-PNA-2012


√  New J. Chem. 2012, 36, 1008-1013

Conformational analysis of seven-membered 1-N-iminosugars by NMR and molecular modelling

J. Pérez-Castells, M. Fontanella, A. Ardá, F. Javier Canãda, M. Sollogoub, Y. Blériot, J. Jiménez-Barbero
NewJChem2012-YB

 

√  J. Carb. Chem. 2011, 30(7-9), 641-654

Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether-Bridged Iminosugars

B. Luo, F. Marcello, J. Désiré, Y. Zhang, M. Sollogoub, A. Kato, I. Adachi, F. J. Canada, J. Jimenez-Barbero, Y. Blériot

JCarbChem-bridged-iminosugars-2011

 

 

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