√   Chem. Eur. J.  2017, ASAP

Multivalency to inhibit and discriminate hexosaminidases

D. Alvarez-Dorta, D. T. King, T. Legigan, D. Ide, I. Adachi, D. Deniaud, J. Désiré, A. Kato, D. J. Vocadlo, S. Gouin, Y. Blériot




√   Org. Biomol. Chem. 2017, ASAP

Selective trihydroxylated azepane inhibitor of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics

J. Bouquet, D. T. King, G. Vadlamani, G. Benzie, B. I. Iorga, D. Ide, I. Adachi, A. Kato, D. J. Vocadlo, B. L. Mark, Y. Blériot, J. Désiré



√   Protein Science 2017, 26 (6), 1161-1170

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

G. Vadlamani, K. A. Stubbs, J. Désiré, Y. Blériot, D. J. Vocadlo, B. L. Mark




√   Org. Lett. 2017, 19, 1040-1043

HF-induced intramolecular C-arylation and C-alkylation/fluorination of 2-aminoglycopyranoses

N. Probst, A. Martin, J. Désiré, A. Mingot, J. Marrot, Y. Blériot, S. Thibaudeau



√   Nat. Chem. 2016, 8, 186-191

Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid

A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinaÿ, J. Jiménez-Barbero, S. Thibaudeau, Y. Blériot




√  J. Med. Chem. 2016, 59, 9350-9369

New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues

L. Zimmermann, I. Das, J. Désiré, G. Sautrey, V. Barros, M. El Khoury, M.-P. Mingeot-Leclercq, J.-L. Décout


√  J. Org. Chem. 2016, 81, 10585-10599

4′-Methoxyphenacyl-Assisted Synthesis of β-Kdo Glycosides

M. Mazur, B. Barycza, M. Tamigney Kenfack, Y. Blériot, C. Gauthier


√  Org. Biomol. Chem. 2015, 13, 10734-10744

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors

V. Cendret, T. Legigan, A. Mingot, S. Thibaudeau, I. Adachi., M. Forcella, P. Parenti, J. Bertrand, F. Becq, C. Norez, J. Désiré, A. Kato, Y. Blériot



√  Chem. Eur. J. 2015, 21, 10513-10521

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings

L. Unione, B. Xu, D. Díaz, S. Martín-Santamaría, A. Poveda, J. Sardinha, A. Pilar Rauter, Y. Blériot, Y. Zhang, F. Javier Cañada, M. Sollogoub, J. Jiménez-Barbero




√  Carbohydr. Res. 2015, 409, 56-62

Synthesis of pyrrolidines-based analogues of aminosugars as N-acetyl glucosaminidase inhibitors

A. T. Tuan, Y. Jagadeesh, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot



 √  Org. Biomol. Chem. 2015, 13, 3446-3456

γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

Y. Jagadeesh, A. T. Tuan, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot



√  Angew. Chem. Int. Ed. 2014, 53(36), 9597-9602

gem-Difluorocarbadisaccharides: Restoring the exo-Anomeric Effect

B. Xu, L. Unione, J. Sardinha, S. Wu, M. Ethève-Quelquejeu,  A. Pilar Rauter, Y. Blériot, Y. Zhang, S. Martín-Santamaría, D. Díaz,  J. Jiménez-Barbero, M. Sollogoub



√ Org. Lett. 2014, 16(21), 5512-5515

Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement

Y. Blériot, N. Auberger, Y. Jagadeesh, C. Gauthier, G. Prencipe, A. Tuan Tran, J. Marrot, J. Désiré, A. Yamamoto, A. Kato, M. Sollogoub



√   Org. Lett. 2014, 16(21), 5516-5519

Synthesis of 1,2-trans-2-acetamido-2-deoxyhomoiminosugars

Y. Blériot, A. Tuan Tran, G. Prencipe, Y. Jagadeesh, N. Auberger, S. Zhu, C. Gauthier, Y. Zhang, J. Désiré, I. Adachi, A. Kato, M. Sollogoub



√  Org. Biomol. Chem. 2014, 12(44), 8977-8996

N- and C-Alkylation of seven-membered iminosugars generate potent glucocerebrosidase inhibitors and F508del-CFTR correctors

J. Désiré, M. Mondon, N. Fontelle, S. Nakagawa, Y. Hirokami, I. Adachi, R. Iwaki, G. W. J. Fleet, D. S. Alonzi, G. Twigg, T. D. Butters, J. Bertrand, V. Cendret, F. Becq, C. Norez, J. Marrot, A. Kato, Y. Blériot



√  Carbohydrate Chemistry 2014, 40, 418-444

Conformationally restricted glycoside derivatives as mechanistic probes and/or inhibitors of sugar processing enzymes and receptors

C. Maaliki, C. Gauthier, O. Massinon, R. Sagar, S. P. Vincent, Y. Blériot



√  Carbohydrate Chem. Prov. Synth. Meth. 2014, 2, 85-96

Synthesis of fluorinated exo-glycals mediated by Selectfluor

G. Eppe, A. Caravano, J. Désiré, S. P. Vincent


  Chem. Commun. 2013, 49(93), 10983-10985

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

M. Mondon, S. Hur, G. Vadlamani, P. Rodrigues, P. Tsybina, A. Oliver, B. L. Mark, D. J. Vocadlo, Y. Blériot



√  Bioorg. Med. Chem. 2013, 21, 4831-4838

Novel imino sugar α-glucosidase inhibitors as antiviral compounds

J. D. Howe, N. Smith, M. J-R. Lee, N. Ardes-Guisot, B. Vauzeilles, J. Désiré, A. Baron, Y. Blériot, M. Sollogoub, D. S. Alonzi, T. D. Butters




√  Bioorg. Med. Chem. 2013, 21, 4803-4812

Skeletal rearrangement of seven-membered iminosugars: Synthesis of (−)-adenophorine, (−)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors

M. Mondon, F. Lecornué, J. Guillard, S. Nakagawa, A. Kato, Y. Blériot



√  Eur. J. Org. Chem. 2013, 13, 2583-2590

β-Cyclodextrin-glycerol dimers: synthesis and NMR conformational analysis

V. Legros, C. Vanhaverbeke, F. Souard, C. Len, J. Désiré



√   Org. Lett. 2012, 14(3), 870-873

Access to D- and L-Imino-Sugar C-Glycosides from a D-Gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

M. Mondon, N. Fontelle, J. Désiré, F. Lecornué, J. Guillard, J. Marrot, Y. Blériot



√  Carbohydr. Res. 2012, 361, 219-224

Synthesis and conformational analysis of bicyclic mimics of α- and β-D-glucopyranosides adopting the biologically relevant 2,5B conformation

L. Amorim, F. Marcelo, J. Désiré, M. Sollogoub, J. Jiménez-Barbero, Y. Blériot



Carbohydr. Res. 2012, 356, 278-281

Cyclodextrins selectively modified on both rims using an O-3-debenzylative post-functionalisation, a consequence of the Sorrento meeting

M. Guitet, S. Adam de Beaumais, Y. Blériot, B. Vauzeilles, Y. Zhang, M. Menand, M. Sollogoub

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√  J. Med. Chem. 2012, 55(13), 6021-6032

A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits HIV-1 Replication

I. Das, J. Désiré, D. Manvar, I. Baussanne, V. N. Pandey, J.-L. Décout


√  New J. Chem. 2012, 36, 1008-1013

Conformational analysis of seven-membered 1-N-iminosugars by NMR and molecular modelling

J. Pérez-Castells, M. Fontanella, A. Ardá, F. Javier Canãda, M. Sollogoub, Y. Blériot, J. Jiménez-Barbero


√  J. Carb. Chem. 2011, 30(7-9), 641-654

Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether-Bridged Iminosugars

B. Luo, F. Marcello, J. Désiré, Y. Zhang, M. Sollogoub, A. Kato, I. Adachi, F. J. Canada, J. Jimenez-Barbero, Y. Blériot





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