√ Eur. J. Org. Chem. 2025, Accepted
Introduction of Structural Diversity at the C2 Position of Unsaturated Iminosugars through Palladium-Catalysed Cross-Coupling Reactions
Q. Joachim, D. Carry, M. di Pasquale, S. Yamamoto, J. Marrot, J. Uziel, A. Kato, N. Lubin-Germain, J. Désiré, A. Ferry, Y. Blériot
√ Org. Lett. 2025, 27(20), 5068-5073
Addition of Lithiated 1,3-dithiane and Nitronate to Sugar-derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues
T. V. Tran, J. Marrot, S. Yamamoto, K. Yoshimura, I. Gillaizeau, C. Nicolas, J. Désiré, A. Kato, N. Auberger, Y. Blériot
√ J. Am. Chem. Soc. 2024, 146 (47), 32618-32626
Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions
M. Armand, A. Nin-Hill, A. Ardá, E. Berrino, J. Désiré, A. Martin-Mingot, B. Michelet, J. Jiménez-Barbero, Y. Blériot, C. Rovira, S. Thibaudeau
√ Carbohydr. Res. 2023, 532, 108903
Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors
J. Désiré, Z. Debbah, D. Gueyrard, J. Marrot, Y. Blériot, A. Kato
CarbohydrRes2023-L-iminosugar-C,C-Glycosides
√ Org. Lett. 2022, 24(25), 4542-4546
Stereoselective access to iminosugar C,C-glycosides from 6-azidoketopyranoses
Z. Debbah, J. Marrot, N. Auberger, J. Désiré, Y. Blériot
OrgLett-Iminosugar-C,C-glycosides-2022
√ J. Org. Chem. 2022, 87(11), 7581-7585
Stereoselective synthesis of 1-C-diethylphosphonomethyl and -difluoromethyl iminosugars from sugar lactams
T. V. Tran, J. Désiré, N. Auberger, Y. Blériot
√ Curr. Med. Chem. 2022, 29 (7), 1271-1292
Sugar-derived amidines and congeners: structures, glycosidase inhibition and applications
Y. Blériot, N. Auberger, J. Désiré
√ Org. Biomol. Chem. 2022, 20, 619-629
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors
J. Bouquet, N. Auberger, R. Ashmus, D. King, A. Bordes, N. Fontelle, S. Nakagawa, Z. Madden, C. Proceviat, A. Kato, J. Désiré, D. J. Vocadlo, Y. Blériot
√ Carbohydr. Res. 2022, 511, 108491
Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif
J. Désiré, Q. Foucart, A. Poveda, G. Gourlaouen, Y. Shimadate, M. Kise, C. Proceviat, R. Ashmus, D. J. Vocadlo, J. Jiménez-Barbero, A. Kato, Y. Blériot
CarbohydrRes2022-Bicyclic-Nojirimycin-C-glycosides
√ Chem. Eur. J. 2021, 27, 11291-11297
Iminosugar C-glycosides work as pharmacological chaperones of NAGLU, a glycosidase involved in MPS IIIB rare disease
S. Zhu, Y. Jagadeesh, A.T. Tran, A. Yamamoto, D. Alonzi, A. Poveda, Y. Zhang, A. Kato, A. Boraston, T. Butters, J. Désiré, J. Charollais-Thoenig, S. Demotz, J. Jiménez-Barbero, M. Sollogoub, Y. Blériot
√ Acc. Chem. Res. 2021, 54(11), 2552-2564
Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity and Interactions
A. Franconetti, A. Arda, J. L. Asensio, Y. Blériot, S. Thibaudeau, J. Jiménez-Barbero
AccChemRes-GlycosylCation-2021
Front Cover of Acc. Chem. Res. 2021
√ Carbohydr. Res. 2021, 501, 108258
Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an Aza Crown IminoSugar structure
A. Bordes, A. Poveda, N. Fontelle, A. Arda, J. Guillard, Y. Bin Ruan, J. Marrot, S. Imaeda, A. Kato, J. Désiré, J. Xie, J. Jiménez-Barbero, Y. Blériot
√ Angew. Chem. Int. Ed. 2021, 60(4), 2036-2041
Insight in the Ferrier rearrangement by combining flash chemistry and Superacids
N. Bhuma, L. Lebedel, H. Yamashita, Y. Shimizu, Z. Abada, A. Ardá, J. Désiré, B. Michelet, A. Martin-Mingot, A. Abou-Hassan, M. Takumi, J. Marrot, J. Jiménez-Barbero, A. Nagaki, Y. Blériot, S. Thibaudeau
√ Synthesis 2021, 53 (5), 904-924
Contributing to the Study of Enzymatic and Chemical Glycosyl Transfer Through the Observation and Mimicry of Glycosyl Cations
Y. Blériot
Synthesis-glycosylCations-2021
√ Org. Lett. 2020, 22(6), 2344-2349
Synthesis, conformational analysis and complexation study of an iminosugar-aza-crown, a sweet chiral cyclam analog
A. Bordes, A. Poveda, T. Troadec, A. Franconetti, A. Ardá, F. Perrin, M. Ménand, M. Sollogoub, J. Guillard, J. Désiré, R. Tripier, J. Jiménez-Barbero, Y. Blériot
√ Angew. Chem. Int. Ed. 2019, 58(39), 13758-13762
Structural and Computational Analysis of 2-Halogeno-Glycosyl Cations in Superacid: An Expansive Platform
L. Lebedel, A. Ardá, A. Martin, J. Désiré, A. Mingot, M. Aufiero, N. Aiguabella Font, R. Gilmour, J. Jiménez-Barbero, Y. Blériot, S. Thibaudeau
√ Org. Biomol. Chem. 2019, 17, 7204-7214
Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C-allyl iminosugar
Q. Foucart, Y. Shimadate, J. Marrot, A. Kato, J. Désiré, Y. Blériot
OrgBiomolChem-Locked-Iminosugars-2019
√ Org. Lett. 2019, 21(12), 4821-4825
Site-selective debenzylation of C-allyl iminosugars enables their stereocontrolled structure diversification at the C-2 position
Q. Foucart, J. Marrot, J. Désiré, Y. Blériot
OrgLett-Selective-debenzylation-2019
√ ACS Central Science 2019, 5(5), 781-788
Defining the SN1 side of glycosylation reactions: stereoselectivity of glycopyranosyl cations
T. Hansen, L. Lebedel, W. A. Remmerswaal, S. van der Vorm, D. P. A. Wander, M. Somers, H. S. Overkleeft, D. V. Filippov, J. Désiré, A. Mingot, Y. Blériot, G. A. van der Marel, S. Thibaudeau, J. D. C. Codée
Front Cover of ACS Cent. Sci.
√ J. Carb. Chem. 2019, 38:2, 139-149
Bi(OTf)3-mediated intramolecular epoxide opening for bicyclic azepane synthesis
S. Zhu, A. T. Tran, Y. Hirokami, G. Gontard, O. Khaled, Y. Zhang, A. Kato, Y. Blériot, M. Sollogoub
J-Carb-Chem-Bicyclic-Azepanes-2019
√ Carbohydr. Res. 2019, 472, 65-71
Lewis acid-catalysed nucleophilic opening of a bicyclic hemiaminal followed by ring contraction: access to functionalized L-idonojirimycin derivatives
N. Auberger, B. Onfroy, N. Fontelle, Q. Foucart, Y. Blériot
CarbohydrRes-Idonojirimycin-2018
√ Eur. J. Org. Chem. 2018, 40, 5477-5488
2-Acetamido-2-deoxy-L-iminosugar C-alkyl and C-aryl glycosides: synthesis and glycosidase inhibition
N. Fontelle, A. Yamamoto, A. Arda, J. Jiménez-Barbero, A. Kato, J. Désiré, Y. Blériot
EurJOC-Acetamido-C-Iminosugars-2018
Feature Cover of Eur. J. Org. Chem.
√ Org. Biomol. Chem. 2017, 15, 9297-9304
2017 Hot Articles and Cover Page in Organic and Biomolecular Chemistry
In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease
A. Kato, I. Nakagome, S. Nakagawa, K. Kinami, I. Adachi, S. F. Jenkinson, J. Désiré, Y. Blériot, R. J. Nash, G. W. J. Fleet, S. Hirono
OBC-HexA-Chaperone-Tay-Sachs-2017
Front Cover of Org. Biomol. Chem.
√ Nat. Commun. 2017, 8:115
Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia
mallei lipopolysaccharide O-antigens
M. Tamigney Kenfack, M.Mazur, T. Nualnoi, T. L. Shaffer, A. Ngassimou, Y.Blériot, J. Marrot, R. Marchetti, K. Sintiprungrat, N. Chantratita, A. Silipo, A. Molinaro, D. P. AuCoin, M. N. Burtnick, P. J. Brett & Ch. Gauthier
√ Carbohydrate Chem. Prov. Synth. Meth. 2017, Part I: Synthetic Methods, Chapter 6
One Step Preparation of Protected N–tert-Butanesulfinyl d-ribo and d-xylo furanosylamines from Related Sugar Hemiacetals
Cocaud, C., Nicolas, C., Désiré, J., Martin. O. R.
√ Chem. Eur. J. 2017, 23 (38), 9022-9025
Multivalency to inhibit and discriminate hexosaminidases
D. Alvarez-Dorta, D. T. King, T. Legigan, D. Ide, I. Adachi, D. Deniaud, J. Désiré, A. Kato, D. J. Vocadlo, S. Gouin, Y. Blériot
√ Org. Biomol. Chem. 2017, 15, 4609-4619
Selective trihydroxylated azepane inhibitor of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics
J. Bouquet, D. T. King, G. Vadlamani, G. Benzie, B. I. Iorga, D. Ide, I. Adachi, A. Kato, D. J. Vocadlo, B. L. Mark, Y. Blériot, J. Désiré
√ Protein Science 2017, 26 (6), 1161-1170
Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance
G. Vadlamani, K. A. Stubbs, J. Désiré, Y. Blériot, D. J. Vocadlo, B. L. Mark
√ Org. Lett. 2017, 19, 1040-1043
HF-induced intramolecular C-arylation and C-alkylation/fluorination of 2-aminoglycopyranoses
N. Probst, A. Martin, J. Désiré, A. Mingot, J. Marrot, Y. Blériot, S. Thibaudeau
√ Nat. Chem. 2016, 8, 186-191
Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid
A. Martin, A. Arda, J. Désiré, A. Martin-Mingot, N. Probst, P. Sinaÿ, J. Jiménez-Barbero, S. Thibaudeau, Y. Blériot
NatChem-GlycosylCation-News&Views-2016
√ J. Med. Chem. 2016, 59, 9350-9369
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues
L. Zimmermann, I. Das, J. Désiré, G. Sautrey, V. Barros, M. El Khoury, M.-P. Mingeot-Leclercq, J.-L. Décout
√ J. Org. Chem. 2016, 81, 10585-10599
4′-Methoxyphenacyl-Assisted Synthesis of β-Kdo Glycosides
M. Mazur, B. Barycza, H. Andriamboavonjy, S. Lavoie, M. Tamigney Kenfack, A. Laroussarie, Y. Blériot, C. Gauthier
√ Org. Biomol. Chem. 2015, 13, 10734-10744
Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors
V. Cendret, T. Legigan, A. Mingot, S. Thibaudeau, I. Adachi., M. Forcella, P. Parenti, J. Bertrand, F. Becq, C. Norez, J. Désiré, A. Kato, Y. Blériot
√ Chem. Eur. J. 2015, 21, 10513-10521
Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings
L. Unione, B. Xu, D. Díaz, S. Martín-Santamaría, A. Poveda, J. Sardinha, A. Pilar Rauter, Y. Blériot, Y. Zhang, F. Javier Cañada, M. Sollogoub, J. Jiménez-Barbero
√ Carbohydr. Res. 2015, 409, 56-62
Synthesis of pyrrolidines-based analogues of aminosugars as N-acetyl glucosaminidase inhibitors
A. T. Tuan, Y. Jagadeesh, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot
CarbohydrRes-pyrrolidines-2015
√ Org. Biomol. Chem. 2015, 13, 3446-3456
γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP
Y. Jagadeesh, A. T. Tuan, B. Luo, N. Auberger, J. Désiré, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Blériot
√ Nature Communications 2014, 5, 5354
Site-selective hexa-hetero-functionalization of a-cyclodextrin an archetypical C6-symmetric concave cycle
B. Wang, E. Zaborova, S. Guieu, M. Petrillo, M. Guitet, Y. Blériot, M. Ménand, Y. Zhang & M. Sollogoub
√ Angew. Chem. Int. Ed. 2014, 53(36), 9597-9602
gem-Difluorocarbadisaccharides: Restoring the exo-Anomeric Effect
B. Xu, L. Unione, J. Sardinha, S. Wu, M. Ethève-Quelquejeu, A. Pilar Rauter, Y. Blériot, Y. Zhang, S. Martín-Santamaría, D. Díaz, J. Jiménez-Barbero, M. Sollogoub
√ Org. Lett. 2014, 16(21), 5512-5515
Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement
Y. Blériot, N. Auberger, Y. Jagadeesh, C. Gauthier, G. Prencipe, A. Tuan Tran, J. Marrot, J. Désiré, A. Yamamoto, A. Kato, M. Sollogoub
√ Org. Lett. 2014, 16(21), 5516-5519
Synthesis of 1,2-trans-2-acetamido-2-deoxyhomoiminosugars
Y. Blériot, A. Tuan Tran, G. Prencipe, Y. Jagadeesh, N. Auberger, S. Zhu, C. Gauthier, Y. Zhang, J. Désiré, I. Adachi, A. Kato, M. Sollogoub
√ Org. Biomol. Chem. 2014, 12(44), 8977-8996
N- and C-Alkylation of seven-membered iminosugars generate potent glucocerebrosidase inhibitors and F508del-CFTR correctors
J. Désiré, M. Mondon, N. Fontelle, S. Nakagawa, Y. Hirokami, I. Adachi, R. Iwaki, G. W. J. Fleet, D. S. Alonzi, G. Twigg, T. D. Butters, J. Bertrand, V. Cendret, F. Becq, C. Norez, J. Marrot, A. Kato, Y. Blériot
√ Carbohydrate Chemistry 2014, 40, 418-444
Conformationally restricted glycoside derivatives as mechanistic probes and/or inhibitors of sugar processing enzymes and receptors
C. Maaliki, C. Gauthier, O. Massinon, R. Sagar, S. P. Vincent, Y. Blériot
√ Carbohydrate Chem. Prov. Synth. Meth. 2014, 2, 85-96
Synthesis of fluorinated exo-glycals mediated by Selectfluor
G. Eppe, A. Caravano, J. Désiré, S. P. Vincent
√ Chem. Commun. 2013, 49(93), 10983-10985
Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams
M. Mondon, S. Hur, G. Vadlamani, P. Rodrigues, P. Tsybina, A. Oliver, B. L. Mark, D. J. Vocadlo, Y. Blériot
√ Bioorg. Med. Chem. 2013, 21, 4831-4838
Novel imino sugar α-glucosidase inhibitors as antiviral compounds
J. D. Howe, N. Smith, M. J-R. Lee, N. Ardes-Guisot, B. Vauzeilles, J. Désiré, A. Baron, Y. Blériot, M. Sollogoub, D. S. Alonzi, T. D. Butters
√ Chem. Eur. J. 2013, 19(43), 14581-14590
Conformational selection in glycomimetics: Human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative
P. Vidal, V. Roldos, M. del Carmen Fernandez-Alonso, B. Vauzeilles, Y. Blériot, F. J. Canada, S. André, H.-J. Gabius, J. Jimenez-Barbero, J. F. Espinosa, S. Martin-Santamaria
√ J. Org. Chem. 2013, 78(15), 7380-7397
C- Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB-l-isoDMDP Compared to Miglitol and Miglustat
S. F. Jenkinson, D. Best, A. W. Saville, J. Mui, R. F. Martinez, S. Nakagawa, T. Kunimatsu, D. S. Alonzi, T. D. Butters, C. Norez, F. Becq, Y. Blériot, F. X. Wilson, A. C. Weymouth-Wilson, A. Kato, G. W. J. Fleet
√ Bioorg. Med. Chem. 2013, 21, 4803-4812
Skeletal rearrangement of seven-membered iminosugars: Synthesis of (−)-adenophorine, (−)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors
M. Mondon, F. Lecornué, J. Guillard, S. Nakagawa, A. Kato, Y. Blériot
√ Eur. J. Org. Chem. 2013, 13, 2583-2590
β-Cyclodextrin-glycerol dimers: synthesis and NMR conformational analysis
V. Legros, C. Vanhaverbeke, F. Souard, C. Len, J. Désiré
√ Org. Lett. 2012, 14(3), 870-873
Access to D- and L-Imino-Sugar C-Glycosides from a D-Gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy
M. Mondon, N. Fontelle, J. Désiré, F. Lecornué, J. Guillard, J. Marrot, Y. Blériot
OrgLett-Iminosugar-C-glycosides-2012
√ Carbohydr. Res. 2012, 361, 219-224
Synthesis and conformational analysis of bicyclic mimics of α- and β-D-glucopyranosides adopting the biologically relevant 2,5B conformation
L. Amorim, F. Marcelo, J. Désiré, M. Sollogoub, J. Jiménez-Barbero, Y. Blériot
CarbohydrRes-Conformations-2012
√ Carbohydr. Res. 2012, 356, 278-281
√ J. Med. Chem. 2012, 55(13), 6021-6032
A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits HIV-1 Replication
I. Das, J. Désiré, D. Manvar, I. Baussanne, V. N. Pandey, J.-L. Décout
√ New J. Chem. 2012, 36, 1008-1013
Conformational analysis of seven-membered 1-N-iminosugars by NMR and molecular modelling
√ J. Carb. Chem. 2011, 30(7-9), 641-654
Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether-Bridged Iminosugars
B. Luo, F. Marcello, J. Désiré, Y. Zhang, M. Sollogoub, A. Kato, I. Adachi, F. J. Canada, J. Jimenez-Barbero, Y. Blériot
JCarbChem-bridged-iminosugars-2011